Abstract
A general synthetic approach has been developed for the synthesis of a key intermediate (6) that can be elaborated into several ophthalmic prostaglandins and their derivatives. Using these strategy, we have obtained (±)-bimatoprost (1) and its analog, (±)-homobimatoprost (5).
GRAPHICAL ABSTRACT
ACKNOWLEDGMENT
The authors thank C. Satyanarayana, CEO, Aptuit Laurus Private Ltd., for his encouragement.