Abstract
One-pot synthesis of 3,4-diaryl substituted 2(5H)-furanones was established and its commercial application has been demonstrated by accomplishing total synthesis of rofecoxib, under mild reaction conditions, with good yields and purity.
GRAPHICAL ABSTRACT
ACKNOWLEDGMENTS
We are grateful to the management of the Zydus Group for encouragement. We thank the analytical department for providing analytical support.
Notes
a Reaction completion time monitored with TLC.
b Purity of compounds analyzed by HPLC at λ max 220 nm using column ODS C-18, 150 cm × 4.6 mm × 4 µm on AGILENT 1100.
ZRC Communication No. 327 (part of A. Argade's PhD work).