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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 42, 2012 - Issue 21
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Original Articles

Synthesis and Characterization of Related Substances of Deferasirox, an Iron (Fe3+) Chelating Agent

, , , &
Pages 3200-3210 | Received 17 Dec 2010, Published online: 17 Aug 2012
 

Abstract

Deferasirox is an orally active iron chelating agent, and during process development for deferasirox, we observed six related substances (impurities), namely deferasirox methyl ester, deferasirox salicylyl derivative, deferasirox ethyl ester, deferasirox methoxy carbonyl derivative, bis(salicyl)imide, and deferasirox-2-isomer. The present work describes the detection, origin, synthesis, and characterization of these related substances.

GRAPHICAL ABSTRACT

ACKNOWLEDGMENTS

The authors gratefully acknowledges the management of Aurobindo Pharma Limited for allowing us to carry out this research work. The authors are also thankful to the colleagues of the Chemical Research Department and Analytical Research Department for their cooperation.

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