Simple and Reliable Protocol for Metal-Free Assembling of the Bibrachial Schiff Bases and Their Reduced Derivatives Bearing Amino Acids or Short Peptide Residues

Abstract

A simple and efficient protocol is developed for the preparation of bibrachial chiral heterodentate ligands bearing two amino acid or peptide side chains on different scaffolds.

GRAPHICAL ABSTRACT

Keywords:

• Amino acid
• heterodentate ligands
• peptides
• Schiff base

ACKNOWLEDGMENTS

This study was performed with financial support by the Byelorussian Foundation for Basic Research (Project No. Kh08R-051), the Russian Foundation for Basic Research (Project No. 08-03-90 025), and partly by a grant from the president of the Russian Federation (Project No. MK-3588.2008.3).

Notes

^a A mixture of intramolecular cyclization products was isolated.

^a Oily substances.

^b Spectra recorded in CDCl₃.

^c Spectra recorded in D₂O.

^a Spectra recorded in D₂O.