Abstract
An expeditious one-pot synthesis of substituted pyrimidinone derivatives with aromatic aldehydes, cyclopentanone, and urea (or thiourea) was developed with boric acid (10 mol%) and glycerol (0.1 mL) in aqueous medium at 45–50 °C. The methodology is simple, highly efficient, and high yielding. The idea behind this methodology is that boric acid, being a weak acid, behaves as a strong acid in presence of glycerol in aqueous medium.
GRAPHICAL ABSTRACT
ACKNOWLEDGMENTS
We thank the CAS Instrumentation Facility, University of Calcutta, for spectral data. We also acknowledge a grant received from the University Grants Commission Major Project, F. No. 37-398/2009.