Abstract
A novel series of potential biologically active new cinnamoyl amides were synthesized in good yield and short reaction times. We have studied the one-pot, solvent-free reaction of cinnamic acid derivatives with aromatic amines using 1,3-dicyclohexylcarbodiimide under microwave irradiation in the presence of small quantities of dimethylformamide to improve energy transfer.
GRAPHICAL ABSTRACT
![](/cms/asset/ac18fe84-d661-4ce5-8028-a8c9062a037e/lsyc_a_604148_o_uf0001.gif)
ACKNOWLEDGMENTS
The authors thank Antonio Marchal Igrain and Juan Jesús López González from University of Jaén, Spain, for their kindness for measuring NMR spectra.
Notes
a MW conditions: P = 180 W, reaction time: 10 min.
b Cinnamic acid–amine–DCC.
c Isolated yields.
a Reaction conditions: cinnamic acid (20 mmol), amine (20 mmol), DCC (20 mmol), DMF (3 drops), 120 W.
b Method MW: The temperature was controlled throughout the reaction and evaluated by infrared detector, which indicated the surface temperature after calibration with an optical fibre.
c Method Δ: The temperature was controlled using a digital thermometer inside the reaction mixture.
d Yields (%) refer to those of pure isolated products properly characterized by spectroscopic data (1H, 13C NMR, MS).