Spectral Characterization of Novel 3-Phenyl-2-Substituted Quinazoline and Fused Quinazoline Derivatives

Abstract

3-phenyl-2-thioxo-quinazolin-4(3H)one 1 was utilized for the construction of some novel 2-substituted quinazolin-4(3H)one derivatives through the formation of 2-hydrazinyl quinazolinone, which was used as the key starting material for the synthesis of 2-heteryl quinazolines via the reaction with one carbon donors, β-diketones and β-ketoester. Infrared, ¹H NMR, and mass spectra of the synthesized compounds were discussed. Some of them showed promising anti-inflammatory activity.

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GRAPHICAL ABSTRACT

Keywords:

• Anti-inflammatory
• hydrazino
• pyrazolone
• pyrazolo quinazoline
• quinazolin-4(3H)one
• triazolthione