Abstract
The C-S cross coupling of pharmaceutically active barbituric acid derivatives has been achieved by the interaction of selective monobromobarbituric acid with thioureas in an aqueous medium. This method is applicable for simple thiourea as well as monosubstituted thioureas, and corresponding products are obtained in good yield.
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GRAPHICAL ABSTRACT
ACKNOWLEDGMENT
The authors are thankful to Shri Shivaji Science College, Akola, Indian Institute of Science, Bangalore, and Vishnu Chemical, Hyderabad, for recording the IR, NMR, and mass spectra. Thanks are also due to Dr. S. G. Charalwar, Principal, Shri M. M. College of Science and Dr. L. J. Paliwal, Head, Department of Chemistry, RTM Nagpur University, Nagpur, for encouragement and providing necessary facilities.