Abstract
A series of 2-amino-3-cyano-4-aryl-5-oxo-7,7-dimethyl-1,4,6,8-tetrahydroquinolines were prepared by a one-pot, four-component condensation of aromatic aldehydes, dimedone, malononitrile, and ammonium acetate using K2CO3 as a catalyst in aqueous medium under sonic conditions. This protocol, being a single-step reaction, has the advantages of operational simplicity and minimal environmental impact. The synthesized compounds were confirmed through spectral characterization using infrared, 1H NMR, 13C NMR, and CHN analysis.
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GRAPHICAL ABSTRACT
ACKNOWLEDGMENTS
One of the authors, S. H. S. A., gratefully acknowledges the Sana University, Yemen, for a fellowship, and the authors thank the VGST Department of Science and Technology, government of Karnataka, for the CESEM Award Grant No. 24 (2010-2011).
Notes
a 10 mol%. Ultrasound (at 26 °C).
b Isolated yields.
c Reflux in water. ND, not detected.
a Isolated yields.
a K2CO3 (5 mol%).
b Ultrasound (at 26 °C).
c Isolated yields.
a Isolated yields.
b Novel compounds.ND, not detected.