Abstract
An efficient and simple protocol for the Meyer–Schuster rearrangement of propargyl alcohols into α,β-unsaturated carbonyl compounds has been developed using catalytic amounts of p-toluenesulfonic acid in 1,2-dichloroethane.
GRAPHICAL ABSTRACT
Notes
a Reaction conditions: 1-phenyl-2-propyn-1-ol (1a, 1.0 mmol), solvent (3.0 mL), in air.
b Yields are based on 2a, determined by crude 1H NMR using dibromomethane as the internal standard.
c As observed by 1H NMR.
d Isolated yield.
a Reaction conditions: propargyl alcohols (1.0 mmol), PTSA (30 mol%), DCE (3.0 mL), in air.
b Isolated yields.