Abstract
An efficient protocol for the synthesis of new functionalized indenes 3 was successfully realized. Thus the coupling reaction of allyl acetate 2 with Grignard reagents in the presence of a catalytic amount of LiCuBr2 at low temperature afforded pure ethyl 1-alkyl-1H-indenes-2-carboxylate 3 in good yields.
GRAPHICAL ABSTRACT
ACKNOWLEDGMENT
The authors thank Professor Jacques Lebreton (University of Nantes, France) for logistical help.
Notes
a Yields refer to the pure isolated products characterized by 1H NMR, 13C NMR, and HRMS.
a Yields refer to the pure isolated products characterized by 1H and 13C NMR.