Abstract
Herein, we describe a clean and ecocompatible pathway for both N-benzoylation and N-acetylation of anilines, amines, diamines, and aminoalcohols using three enol esters with good yields. We have improved the use of vinyl benzoate for the direct introduction of a benzamido-moiety under solvent- and activation-free conditions. The recovered amides are easily isolated by crystallization.
GRAPHICAL ABSTRACT
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ACKNOWLEDGMENT
We thank M. Loïc Cornelissen for his contribution for the preparation of this article.
Notes
a 1 mmol of amine, the appropriate amount of enol ester, without solvent, under magnetic stirring at room temperature.
b After total conversion.
c Isolated yields of pure acetamides after purification by simple workup or by crystallization.
a 1 mmol of amine, 3 mmol of isopropenyl acetate, without solvent, under magnetic stirring at room temperature.
b After total conversion.
c Isolated yields of pure acetamides after purification by simple workup or by crystallization.
a 1 mmol of amine, 3 mmol of vinyl benzoate, without solvent, under magnetic stirring at room temperature.
b After total conversion.
c Isolated yields of pure benzamides after purification by crystallization.
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