Synthesis and Bioactivity of Benzothiazaphosphepines and Relevant Phosphonates as Antioxidant/Antidiabetic Agents

Abstract

An efficient approach to a new series of benzothiazaphosphepines and their derived phosphonates in good yields (64–75%) was reported. The strategy relied on the reactions of the easily available 2-arylmethylene-aminobenzenethiols with different types of Wadsworth–Horner–Emmons (WHE) reagents in dimethylformamide (DMF)/lithium hydride (LiH) solution. All new compounds were bioscreened and showed, in vitro, moderate to good antioxidant and antidiabetic activities.

GRAPHICAL ABSTRACT

Keywords:

• Antioxidants/antidiabetics
• N,S,P-heterocycles
• phosphonates
• phosphonyl carbanions
• Schiff bases

ACKNOWLEDGMENT

The authors thank the Central Laboratory, Faculty of Pharmacy, Alexandria University, Egypt, for carrying out the pharmacological screening.

Notes

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