Abstract
This article highlights Ni-catalyzed cross-electrophile coupling of halogenated pyridines with secondary alkyl bromides using zinc as the terminal reductant. With this protocol, we have successfully achieved different alkyl-substituted pyridines in moderate to excellent yields.
GRAPHICAL ABSTRACT
Notes
a Reaction conditions: 1a (0.15 mmol, 100 mol%), 2a (0.30 mmol, 200 mol%), NiBr2 (10 mol%), ligand (10 mol%), Zn (300 mol%), Bu4NBr (50 mol%), MgCl2 (0.15 mmol)–pyridine (1:1), and DMA (1 mL).
b Isolated yield.
c 20% ligand was used.
a Reaction conditions: alkyl bromide (0.15 mmol), halogenated pyridine (0.30 mmol, 200 mol%), NiBr2 (10 mol%), ligand (10 mol%), Zn (300 mol%), Bu4NBr (50 mol%), MgCl2 (0.15 mmol)–pyridine (1:1), DMA (1 mL).
b Isolated yield.
Authors Huiyan Liu and Zhuye Liang contributed equally to this work.
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