Abstract
Several 5-substituted 1H-tetrazoles were prepared in water or isopropanol/water mixtures using microwave heating. Good yields were obtained for the [2 + 3] cycloaddition of sodium azide with aryl nitriles, aliphatic nitriles, and vinyl nitriles when catalyzed by scandium triflate. The reactions were typically heated for 1 h at 160 °C in a 3:1 isopropanol/water mixture to obtain the best yields.
GRAPHICAL ABSTRACT
Notes
a 8 mmol of NaN3 and 0.4 equiv of Sc(OTf) 3 .xH2O were used with nitrile 1h.
a 8 mmol of NaN3 and 0.4 equiv of Sc(OTf) 3 .xH2O were used with nitrile 1s.