Direct Waste-Free Synthesis of Amides from Nonactivated Carboxylic Acids and Amines: Application to the Synthesis of Tetrahydroisoquinolines

Abstract

An efficient, waste-free protocol has been developed for the synthesis of amides directly from nonactivated carboxylic acids and amines without any tedious purification. Fatty acids were also converted into corresponding amides by reaction with nonactivated amines. The synthesized amides were cyclized to tetrahydroisoquinolines in good yields.

GRAPHICAL ABSTRACT

Keywords:

• Amides
• nonactivated amines
• nonactivated carboxylic acids
• tetrahydroisoquinolines
• waste-free synthesis

ACKNOWLEDGMENT

The authors are grateful to the director of the institute for providing necessary facilities.

SUPPORTING INFORAMTION

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