Phosphine-Free Suzuki Cross-Coupling Reaction Using an Efficient and Reusable Pd Catalyst in an Aqueous Medium Under Microwave Irradiation

Abstract

We report here an improved, highly efficient, and general method for the ligand-free Suzuki cross-coupling reaction to the synthesis of biaryls, bipyridyls, thienylpyridine, and allylphenols. Microwave irradiation of (het)aryl halides and (hetaryl, allyl)arylboronic acid N-methyl-iminodiacetic acid (MIDA) ester, using polyurea microencapsulated palladium catalyst (Pd EnCat 30), gave the coupling adducts 1a–x in excellent yields in just 10–18 min.

GRAPHICAL ABSTRACT

Keywords:

• Microwave irradiation
• Pd EnCat30
• phosphine-free reactions
• organoboronic acid MIDA ester
• Suzuki coupling

SUPPLEMENTAL MATERIAL

Full experimental procedures and characterization data for all synthesized compounds for this article can be accessed on the publisher’s website.