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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 47, 2017 - Issue 15
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Original Articles

Synthesis of cyclopropa[c]indeno[1,2-b]quinolines through a MCR/Staudinger/aza-Wittig sequence

, , , , , ORCID Icon & show all
Pages 1368-1374 | Received 30 Sep 2016, Published online: 16 Jun 2017
 

ABSTRACT

Spirocyclopropanes were prepared from aromatic aldehydes, 1,3-indandione and acetophenones through a halogenation/SN2-displacement/Michael-initiated ring-closing sequence by a pyridinium-ylide-assisted multicomponent reaction, and their further use was also researched in the construction of cyclopropa[c]indeno[1,2-b]quinolines through subsequent Staudinger/aza-Wittig reactions.

GRAPHICAL ABSTRACT

Acknowledgment

We would like to appreciate Professor Shi-Jie Liu from the State University of New York for providing linguistic assistance during the preparation of this manuscript.

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