Novel oxidative aromatic alkene cleavage with sodium nitrite under mild conditions

ABSTRACT

We have developed a simple and practical process for the oxidation of aromatic alkene to the corresponding carbonyl compounds using NaNO₂ as an oxidant. The practical utility of this oxidative process has been demonstrated in the gram-scale oxidation of 1-(tert-butyl)-4-vinylbenzene.

GRAPHICAL ABSTRACT

KEYWORDS:

• Aromatic alkene
• carbon–carbon double bond cleavage
• sodium nitrite

Acknowledgments

The authors are grateful to the NSF of China (No: 21462002), Natural Science Foundation of Jiangxi Province (No: 20161BAB203096) for financial support.

Additional information

Funding

This work was supported by the National Natural Science Foundation of China [Grant Number 21462002] and Natural Science Foundation of Jiangxi Province [Grant Number 20161BAB203096].