Synthesis and characterization of oxazine bearing pyridine scaffold as potential antimicrobial agents

ABSTRACT

A series of novel compounds 1-((1-(4-(2H-benzo[e][1,3]oxazin-3(4H)-yl)phenyl)ethylidene)amino)-6-((benzylidene)amino)-2-oxo-4-phenyl-1,2-dihydropyridine-3,5-dicarbonitriles (7a–o) were synthesized by a sequence of multistep reactions. IR, ¹H NMR, ¹³C NMR, and mass spectral techniques were used to confirm the structures newly synthesized compounds. Antimicrobial activity of the title compounds (7a–o) was studied against strains of bacteria (Staphylococcus aureus and Streptococcus pyogenes, Escherichia coli and Pseudomonas aeruginosa) and fungi (Candida albicans, Aspergillus niger and Aspergillus clavatus) by serial dilution method. Compounds 7f and 7k exhibited significant antimicrobial activity.

GRAPHICAL ABSTRACT

KEYWORDS:

• 2-Oxopyridine
• antimicrobial activity
• Mannich reaction
• Michel addition
• oxazine

Additional information

Funding

Authors are grateful to the UGC, New Delhi and Department of Science and Technology, New Delhi (DST-FIST-SR/FST/CSI-212/2010) for financial support under the NON-SAP and DST-FIST programs respectively.