ABSTRACT
An expeditious one pot method has been developed for the synthesis of 2,4-disubstituted thiazoles under solvent free conditions via a multicomponent approach. Substituted thiazoles were synthesized with high yields by the reaction of cyclic ketones, thiosemicarbazide, and phenacyl bromides or 3-(2-bromoacetyl)-2H-chromen-2-ones in a shorter reaction time with high purity via simple purification technique.
GRAPHICAL ABSTRACT
Acknowledgments
The authors are thankful to the Director, National Institute of Technology, Warangal, Telangana, India for providing the facilities. K. S. thanks to the MHRD, India for fellowship.