Pd-catalyzed regioselective C-H chlorination of disubstituted 1,2,3-triazoles

ABSTRACT

This paper mainly studied Pd-catalyzed regioselective chlorination of disubstituted 1,2,3-triazoles directed by the 1,2,3-triazole ring. A series of regioselective chlorinated products were synthesized in 47–86% yields using Pd(OAc)₂ as a catalyst and CuCl₂ as a chlorinated reagent. This method provides a new mean for the synthesis of 1,2,3-triazole halides which combines the formation of C-X bond with C-H activation.

GRAPHICAL ABSTRACT

KEYWORDS:

• 1,2,3-Triazole
• C-H activation
• chlorination
• Pd catalyst

Additional information

Funding

This work is supported by grants from the personnel training program of Kunming University of Science and Technology (KKSY201307094).