An overview on synthetic strategies to coumarins

ABSTRACT

Coumarins units have recently emerged as a hot topic of research due to their diverse applications. Their synthesis is partly based on classical methodologies such as Pechmann reaction or Knoevenagel condensation, but it also sparked the discovery of completely new pathways. In very recent years so-called vertically expanded coumarins were synthesized, effectively expanding the portfolio of existing architectures. This review serves as a guide through synthesis strategies to coumarins.

GRAPHICAL ABSTRACT

KEYWORDS:

• Baylis–Hillman
• coumarins
• Horner–Wadsworth–Emmons
• Knoevenagel
• Pechmann
• Perkin
• Umpolung reaction