Base promoted synthesis of 3-benzyl-2,5-diarylpyrazines from arylaldehydes and α-amino ketones

Abstract

A novel approach to 3-benzyl-2,5-diarylpyrazine derivatives from α-amino ketones hydrochloride and arylaldehydes in the presence of Na₂CO₃ has been developed. In contrast with the classic synthetic methods of pyrazines, this protocol does not need additional oxidants and is more friendly to environment.

Graphical Abstract

Keywords:

• α-amino ketones
• 3-Benzyl-2,5-diarylpyrazines
• heterocycles
• condensation

Additional information

Funding

This work was supported by the Talent Introduction Research Project of Shaanxi Xueqian Normal University [2017DS03], the Science Foundation of Shaanxi Xueqian Normal University [2018YBKJ33].