Abstract
A new synthetic approach to 1,2,4-thiadiazoles using tetra(n-butyl)ammonium peroxydisulfate via oxidative dimerization of thioamides is described. This new oxidative protocol is simple, highly efficient, and allows the practical synthesis of 1,2,4-thiadiazoles from various primary thioamides in good to excellent yields.
Graphical Abstract
![](/cms/asset/ad6e3442-682c-4379-8398-294a3ec9ebad/lsyc_a_1751854_uf0001_c.jpg)
Acknowledgments
The authors thank Woosuk University for supporting this work (2019).