Abstract
A simple and efficient TEMPO-mediated system for aerobic oxidative synthesis of 2-aryl benzoxazoles from readily available benzoxazoles and primary benzylic and hetero benzylic amines is presented in one pot. The reaction proceeds through the ring-opening of benzoxazoles and is followed by oxidative condensation with benzylamines. These metal-free, straightforward reactions worked well with a wide range of substrates, yielding moderate to good yields under mild conditions using air as an external green oxidant.
Graphical Abstract
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Acknowledgments
M. S. Rao is thankful to IIT Patna for his research fellowship and research support. The authors are thankful to SAIF (IIT Patna) for the single crystal XRD facility.