Ultrasound promoted environmentally benign, highly efficient, and chemoselective N-tert-butyloxycarbonylation of amines by reusable sulfated polyborate

Abstract

The sulfated polyborate catalyzed an efficient and chemoselective N-tert-butyloxycarbonylation of amines under ultrasonic irradiation is developed. A broad substrate scope has been demonstrated for N-Boc protection of various primary/secondary amines. It allows converting several aliphatic/aryl/heteroaryl amines, amino alcohol, aminoester, and chiral amines to their N-Boc-protected derivatives under solvent-free conditions with excellent yields. The protocol has several advantages such as easy catalyst, and product isolation, short reaction time, excellent yields, outstanding chemoselectivity, and catalyst recyclability, among others. This makes the process practicable, economical, and environmentally benign.

Graphical Abstract

Keywords:

• Amines
• N-tert-butyloxycarbonylation
• sulfated polyborate
• ultrasound

Acknowledgments

The authors are grateful to Central Instrumentation Facility SPPU, Pune and DST-FIST Instrumentation Facility, Dada Patil College, Karjat for providing spectral analysis. The authors are grateful to Principal, K. J. Somaiya College of Arts, Commerce & Science, Kopargaon.

Correction Statement

This article has been republished with minor changes. These changes do not impact the academic content of the article.