Abstract
A formal asymmetric synthesis of (−)-A26771B (1) has been achieved where optically active glycidol and Noyori asymmetric hydrogenation are applied to introduce asymmetric centers. Commercially available 1,7-octadiyne, (R)-glycidol and acetaldehyde are used as the starting materials. The outlined synthetic strategy involves fewer number of synthetic steps, applying simple chemical transformations.
Graphical Abstract
Acknowledgments
The authors acknowledge NIT Sikkim for infrastructure support and Dr. Sajal Das (NBU), Mr. Joyanta Mondal, and Mr. Susanta Mandal for constant support.