Abstract
An approach for the synthesis of pyrazolo[4,3-c]quinoline derivatives has been developed by the combination of pyrazole-arylamines and β-keto esters via cleavage of C–C bonds. The strategy shows good tolerance and compatibility with a wide range of functional groups. Moreover, this method features simple conditions, generates a series of alkyl substituted pyrazolo[4,3-c]quinoline, and provides the desired products in moderate to good yields.
Graphical Abstract
![](/cms/asset/512c92c5-961a-4c41-ba55-3f0c0df9830b/lsyc_a_2114372_uf0001_c.jpg)
Acknowledgments
Dedicated to our distinguished friend Prof. Baohua Chen on the occasion of his 60th birthday.