Abstract
The asymmetric Diels–Alder reaction of chalcone and isoprene has been accomplished by use of chiral titanium complexes. Notably, an enantiomeric excess as high as 61% and a regioselectivity of 95% have been achieved. The preparation of the chiral titanium complexes is simple and does not require the pre-installation of a chiral auxiliary. This study represents the first example of asymmetric Diels–Alder reaction between chalcone and isoprene.
Acknowledgment
This work was supported by Universiti Malaya Research Grants (IIRG003B-2019 and BK044-2017).
Disclosure statement
The authors confirm that they have no conflict of interest with respect to the work described in this manuscript.