![Sample our Physical Sciences journals, sign in here to start your FREE access for 14 days]({"type":"image" , "src" : "/sda/110819/TOC-Subject-Sample-2021-Physical-Sciences.jpg"})
Abstract
PVP-CMC and PVP-CMC-BA hydrogels were prepared for biomedical applications. These hydrogels were stored under 5°C ± 2°C, 22°C ± 3°C, and 40°C for 180 days to identify their suitable storage condition. At 5°C ± 2°C, hydrogels showed minimum alteration in physical properties. No microbial colonies appeared on PVP-CMC stored at 5°C ± 2°C, but they slowly appeared at 22°C ± 3°C and 40°C after 45 days. FTIR and antibacterial assay demonstrated that boric acid (BA) in hydrogel remained stable for 180 days. PVP-CMC-BA is more bio-stable than PVP-CMC because of BA, an antibacterial agent. Finally, 5°C ± 2°C was recommended as the best storage condition for both PVP-CMC and PVP-CMC-BA hydrogels.
Acknowledgment
The authors are thankful to the Ministry of Education, Youth and Sports of the Czech Republic (MSM 70088352101) for financial support. This article was also created with the partial support of the Operational Programme Research and Development for Innovation co-funded by the European Regional Development Fund (ERDF) and the national budget of the Czech Republic within the framework of the Centre of Polymer Systems project (reg. number: CZ.1.05/2.1.00/03.0111). Moreover, the authors are also thankful to Dr. Vera Kasparkova for providing valuable suggestions during the planning of experimental design for stability study of medicated hydrogels.
Notes
Temp = Temperature.