Abstract
The authors report preparation of chitosan by deacetylation of chitin extracted from shrimp shells. The quality of chitosan depended on the chemical extraction process, the concentration of chemicals used, soaking time, sequence of deproteination, decalcification, and deacetylation. Hydrogels composed of hydroxyethylmethacrylate and chitosan were subsequently prepared and their swelling and ibuprofen delivery kinetics at various chitosan concentrations were studied. The swelling properties of the network varied with the chitosan concentration. Furthermore, the swelling process followed second-order kinetics, while ibuprofen diffusion into the hydrogel showed Fickian behavior.
Notes
*Shrimp shell weight vesus volume (NaOH or HCl);.
**Step 1: deacetylation; step 2: deproteination.
Note. HEMA = 2-Hydroxyethylmethacrylate.
*The yield of chitosan was determined based on oven dry weight of the initial sample.
*g xerogel (not swollen hydrogel;)/g water · h.
**Both n and k were calculated from the slope and intercept of a plot of ln (f) against ln (t) Eq. Equation8.
***The first value indicates chitosan of M v1 = 4.67 while the value in brackets concerns chitosan of Mv2 = 115.64 g mol−1.
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