Porous Chitosan Scaffolds: A Systematic Study for Choice of Crosslinker and Growth Factor Incorporation

Abstract

A systematic study was conducted to evaluate the crosslinker and method of incorporation for bovine serum albumin (BSA) into chitosan hybrid scaffolds (CH-ALG) for better cartilage tissue engineering applications. Formaldehyde and sodium tripolyphosphate were used crosslinkers for fabrication of CH-ALG scaffolds using BSA as growth factor by direct incorporation and microencapsulation methods. An in vitro release study of BSA with maximum release (80%) for scaffolds of formaldehyde crosslinked was found. The present findings show that the CH-ALG hybrid scaffolds have been potential use in biomedical applications.

GRAPHICAL ABSTRACT

Keywords:

• Alginate
• BSA
• chitosan
• crosslinker
• microencapsulation
• release study

Acknowledgements

The authors are thankful to Indian Institute of Technology, Kanpur, and National Centre of Experimental Mineralogy and Petrology, Allahabad, for providing sample characterization facilities.

Notes

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