Phyto-Niosomes: In Vitro Assessment of the Novel Nanovesicles Containing Marigold Extract

Abstract

Herbal compounds, so-called phytoconstituents, illustrate poor absorption by living cells. Phytosomes are advanced form of herbal compounds that show higher absorption rate and bioavailability, which results better than conventional plant extracts. Niosomes, which are made of nonionic surfactants, create better chemical and stability conditions besides lipid vesicles. This study covers the preparation, characterization and cell culture applications of phyto-niosomes of Marigold extract. Before the encapsulation process, extracts of selected plants were prepared and the extract that presents best bioactivity was chosen. The resulting phyto-niosomes were characterized and their biological activities including cytotoxicity, wound healing and antioxidant activity were investigated.

GRAPHICAL ABSTRACT

Keywords:

• Calendula
• cell-based in vitro tests
• encapsulation of herbal extracts
• niosome
• phyto-niosome

Acknowledgments

The authors thank to Prof. O. Alankus Caliskan for the fruitful discussions. The authors gratefully acknowledge EGE LS Company for its support.