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International Journal of Polymeric Materials and Polymeric Biomaterials Volume 66, 2017 - Issue 12
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Original Articles

Improved protein resistance of silicone hydrogels by grafting short peptides for ophthalmological application

Chen XuSchool of Chemistry and Chemical Engineering, Southeast University, Nanjing, China
,
Ruiyu HeSchool of Chemistry and Chemical Engineering, Southeast University, Nanjing, China
,
Binbin XieSchool of Chemistry and Chemical Engineering, Southeast University, Nanjing, China
,
Muhammad IsmailSchool of Chemistry and Chemical Engineering, Southeast University, Nanjing, China
,
Chen YaoSchool of Chemistry and Chemical Engineering, Southeast University, Nanjing, China
,
Jie LuanDepartment of Ophthalmology, Zhongda Hospital Southeast University, Nanjing, China
&
Xinsong LiSchool of Chemistry and Chemical Engineering, Southeast University, Nanjing, ChinaCorrespondence[email protected]
 show all
Pages 618-625 | Received 30 Jul 2016, Accepted 14 Oct 2016, Published online: 04 May 2017
 
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ABSTRACT

A simple and facile approach to impart the antifouling properties of silicone hydrogels was developed in this report. Short peptides were first tethered to silicone hydrogels through terminal amino group-induced epoxy ring-opening click reaction. The modified silicone hydrogels have improved hydrophilicity and protein adsorption resistance because of the formation of zwitterionic structure of the grafted peptides. Furthermore, glycylglycine and diglycyl glycine-modified silicone hydrogel contact lenses were fabricated. They exhibited favorable antifouling property and no damage to rabbits’ eyes after continuous wearing. The short peptide modified silicone hydrogel contact lenses have potential application in ophthalmology.

GRAPHICAL ABSTRACT

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