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International Journal of Polymeric Materials and Polymeric Biomaterials Volume 66, 2017 - Issue 13
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Original Articles

Poly(L-lactide-co-caprolactone)/collagen electrospun mat: Potential for wound dressing and controlled drug delivery

C. R. ReshmiMaterial Research Laboratory, Department of Chemistry, National Institute of Technology Calicut, Calicut, India
,
Tara MenonDepartment of Biotechnology, University of Calicut, Calicut, India
,
Anupama BinoySchool of Biotechnology, Amrita Vishwa Vidyapeetham, Kollam, India
,
Nandita MishraSchool of Biotechnology, Amrita Vishwa Vidyapeetham, Kollam, India
,
K. K. ElyasDepartment of Biotechnology, University of Calicut, Calicut, India
&
A. SujithMaterial Research Laboratory, Department of Chemistry, National Institute of Technology Calicut, Calicut, IndiaCorrespondence[email protected]
Pages 645-657 | Received 30 Jul 2016, Accepted 17 Oct 2016, Published online: 02 May 2017
 
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ABSTRACT

Here we report a novel bioactive electrospun mat based on poly(L-lactide-co-caprolactone) (PLLC) and collagen for wound dressing and sustained drug delivery of gentamicin. PLLC/collagen electrospun mat loaded with 10% gentamicin showed bioactivity for 15 days against Gram-positive and Gram-negative bacteria. The in vitro cell culture of 3T3 fibroblasts confirmed that these electrospun mat provide an increased specific interface area and hydrophilicity to enhance cell attachment, proliferation, and migration. The modified PLLC/collagen mat provided an excellent enhancement in properties of antibacterial wound dressings with a minimum in vitro toxicity and high potency for promoting wound healing stages.

GRAPHICAL ABSTRACT

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