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International Journal of Polymeric Materials and Polymeric Biomaterials Volume 69, 2020 - Issue 6
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Articles

k-Casein upregulates osteogenic differentiation on bone marrow mesenchymal stem cells cultured on agarose microcarriers

Hammed Tanimowo AiyelabeganDepartment of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran; View further author information
,
Malihe EbadiDepartment of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran; View further author information
,
Gholam Ali KardarImmunology, Asthma and Allergy Research Institute, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran; View further author information
,
Nasrin LotfibakhshaieshDepartment of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran; View further author information
,
Farid Abedin DorkooshDepartment of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, IranView further author information
,
Somayeh Ebrahimi_BaroughDepartment of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran; View further author information
&
Esmaeil SadroddinyDepartment of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran; Correspondence[email protected]
View further author information
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Pages 373-380 | Received 19 May 2018, Accepted 05 Jan 2019, Published online: 04 Mar 2019
 
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Abstract

Microcarriers have been used as a three-dimensional substrates for cells cultivation and expansion. The present study aimed to fabricate a novel agarose-κ-casein microsphere, and assess its compatibility towards stem cells attachment, proliferation, survival, differentiation and osteogenic expression. Agarose microspheres were synthesized by emulsion method and activated with CNBr. Cells compatibility of the composite was observed at day 1, 4 and 7 by MTT, in addition FTIR, and SEM analysis were also performed. This microcarrier systems upregulated the expression of osteogenic differentiation markers on bone marrow mesenchymal stem cells cultured on the carrier systems (p < 0.0001).

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Additional information

Funding

This project was funded by Tehran University of Medical Sciences with grant number 96-01-103-34157 and we would like to thank Iran National Science Foundation.

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