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International Journal of Polymeric Materials and Polymeric Biomaterials Volume 69, 2020 - Issue 9
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Articles

Synthesis of polyorganophosphazenes and fabrication of their blend microspheres and micro/nanofibers as drug delivery systems

Rizwan Ullah KhanState Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, P.R. ChinaORCID Iconhttp://orcid.org/0000-0003-1706-5495
ORCID Icon,
Li WangState Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, P.R. ChinaCorrespondence[email protected]
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Haojie YuState Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, P.R. ChinaCorrespondence[email protected]
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Zain-Ul- AbdinState Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, P.R. China
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Fazal HaqState Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, P.R. China
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Muhammad HaroonState Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, P.R. China
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Kaleem-Ur-Rehman NaveedState Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, P.R. China
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Tarig ElshaaraniState Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, P.R. China
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Shah FahadState Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, P.R. China
,
Sicong RenState Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, P.R. China
&
Jun WangState Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, P.R. China
 show all
Pages 545-566 | Received 20 Sep 2018, Accepted 25 Jan 2019, Published online: 01 Apr 2019
 
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Abstract

Four amino acid-based polyorganophosphazenes were synthesized and characterized by 1H NMR, 31P NMR and GPC. Individually, the synthesized polyorganophosphazenes were blended with two commonly used biocompatible polymers, poly (methyl methacrylate) (PMMA) and polylactic-co-glycolic acid (PLGA) to fabricate anticancer drug loaded micro/nanofibers and microspheres. The nature of side groups, blend composition and drug contents were particularly found significant to adjust the surface morphology, hydrolytic degradation and drug loading/release behavior of microspheres. Moreover, higher in vitro drug release rate was observed in acidic medium. Collectively, our findings suggest that amino acid-based polyorganophosphazenes blend’ systems may provide a therapeutic strategy for cancers.

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