Castor oil reinforced polymer hybrids for skin tissue augmentation

Abstract

Polymer hybrids reinforced with castor oil was developed with a combination of different polymers by the freeze-thawing technique. The hybrids in the form of hydrogels were assessed for different physicochemical characterization and in vivo tissue regeneration efficacy. The developed polymer hybrids demonstrated significant cross-linking interaction within the polymer hybrid matrix. In vivo evaluation revealed a superior reepithelialization and skin tissue regeneration efficacy and indicated that the developed polymeric hybrids functionalized with castor oil emulsion could be a potential biomaterial for tissue regeneration.

Graphical Abstract

Keywords:

• Biomaterial
• castor oil
• polymer hybrids
• reepithelialization

Acknowledgments

The authors would like to thank Gokula Education Foundation (GEF, Medical) and Faculty of Pharmacy, M.S. Ramaiah University of Applied Sciences for supporting this project by providing suitable lab and other facilities required.

Disclosure statement

No potential conflict of interest was reported by the author(s).