Terephthalohydrazido cross-linked chitosan hydrogels: synthesis, characterization and applications

Abstract

Two new hydrogels have been synthesized by incorporating terephthalohydrazido linkages into chitosan Schiff base (TCsSB) and chitosan (TCs). They swell at pH 4 more than at pH 9 and 7. TCs has a higher activity against most of the tested microbes as indicated from its lower MIC values than that measured by the reference drugs Vancomycin and Amphotericin B. Evaluation of the cytotoxicity impacts of TCsSB and TCs revealed that they are safe on normal cells of human. Their adsorption capacity toward some heavy metal ions could be arranged as follows: Co⁺² > Ni⁺² > Cu⁺² > Cd⁺² ions.

Graphical abstract

Keywords:

• Antimicrobial activity
• metal ions uptake
• terephthalohydrazido chitosan hydrogels
• swelling ability

Additional information

Funding

The authors are thankful to the Deanship of Scientific Research at Najran University for funding this work through grant research code [NU/ESCI/17/036].