Quercetin-incorporated collagen/chitosan/SiO₂ composite toward the robust antioxidant biomaterials

Abstract

This investigation aims at providing a novel approach to producing high-performance antioxidant material. Indeed, quercetin molecules incorporated into collagen/chitosan/SiO₂ composite through direct interactions have been reported for the first time. Such internal linking has been found as the primary reason for improving the stability of the entire system and enhancing the permanent existence of strongly active biomaterials. Consequently, in vitro antioxidant tests revealed that the obtained materials (denoted as CS/Col/SiO₂/Q) provide outstanding antioxidant activity. Thus the CS/Col/SiO₂/Q sample exhibits cytotoxicity to HepG2, MKN7, and MCF-7 cancer cells. These results demonstrate that the obtained composite turns out to be very promising as a bioactive material for biomedical applications.

Keywords:

• Antioxidant
• collagen
• chitosan
• cytotoxicity
• internal linkage
• quercetin

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The authors acknowledge the support of National Science and Technology under the Basic Science Development Program in the fields of Chemistry, Life Science, Earth Science and Marine Science, Grant No. B2020-DHH-15. This work was also supported by Hue University under the Core Research Group Program, Grant No. NCM.DHH.2020.05.