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Journal of Coordination Chemistry Volume 62, 2009 - Issue 21
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Original Articles

Interaction of Naproxen with transition metals: synthesis, characterization, anti-inflammatory activity and kinetic studies

Sadaf Yaqub Department of Chemistry, Quaid-i-Azam University, Islamabad, Pakistan
,
Ihsan-Ul-Haq Department of Biochemistry, Quaid-i-Azam University, Islamabad, Pakistan
,
Saqib Ali Department of Chemistry, Quaid-i-Azam University, Islamabad, PakistanCorrespondence[email protected]
,
Bushra Mirza Department of Biochemistry, Quaid-i-Azam University, Islamabad, Pakistan
,
Fiaz Ahmed NESCOM, P.O. Box No. 2216, Islamabad, Pakistan
&
Saira Shahzadi Department of Chemistry, GC University, Faisalabad, PakistanCorrespondence[email protected]
Pages 3463-3470 | Received 30 Jan 2009, Accepted 17 Apr 2009, Published online: 22 Sep 2010
 
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Abstract

Coordination complexes of transition metals (Co, Ni, Cu, Fe, Cr, Ru, Ir, Mn, and Zn) with 6-methoxy-α-methyl-2-naphthalene acetic acid (Naproxen) and triphenylphosphine have been synthesized and characterized by conductance, elemental analysis, UV-Vis, AAS, and FT-IR spectroscopy. The elemental analyses data reveal the presence of 1:1 (metal : ligand) stoichiometry and the IR data suggest that naproxen functions as a bidentate ligand in coordination with transition metals. The anti-inflammatory assays of these complexes have significant effect.

Acknowledgement

SA is thankful to Quaid-i-Azam University, Islamabad for financial support.

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