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Abstract
The n-butyltin(IV) complexes, n-BuSnCl3−x(OC6H3(CH3)2-2,4) x (where x = 1–3), have been synthesized in quantitative yields by employing the reaction of n-BuSnCl3 with 2,4-dimethylphenol and sodium acetate in methanol and benzene solvents at room temperature. The complexes have been characterized by elemental analysis, molar conductivity, and FT-IR, 1H- and 13C-NMR, and mass spectral studies. Thermal behavior has been studied by TG–DTA techniques. Lewis acid character of n-BuSn(OC6H3(CH3)2-2,4)3 has been investigated by reacting it with bases such as 2,2′-bipyridine and 1,10-phenanthroline (B), Ph3PO and Ph3AsO (LO) and phosphorus and arsenic donors Ph3P, Ph3As, and As(SPh)3 (L). The formation of 1 : 1 and 1 : 2 (metal : base) coordination compounds [n-BuSn(OC6H3(CH3)2-2,4)3·B] and n-[BuSn(OC6H3(CH3)2-2,4)3·2LO/2L] has been authenticated by physicochemical and IR spectral studies. In order to infer the biological relevance of newly synthesized complexes, the antibacterial activity has been assayed against six bacterial strains Klebsiella pneumoniae, Staphylococcus epidermidis, Staphylococcus aureus, Salmonella typhi, Salmonella paratyphi, and Escherichia coli. In this study, n-BuSnCl2(OC6H3(CH3)2-2,4) and n-BuSnCl(OC6H3(CH3)2-2,4)2 showed better activity than precursor and ligand, while n-BuSn(OC6H3(CH3)2-2,4)3 did not exhibit improved activity.
Acknowledgments
S. Sharma is grateful to CSIR, New Delhi, for providing a Junior Research Fellowship (Joint CSIR-UGC). The authors thank the Department of Science and Technology (DST) Government of India, New Delhi for providing financial assistance for FT-IR Spectrometer facility to Chemistry Department under its FIST program. They also thank the Sophisticated Analytical Instrument Facility, Punjab University Chandigarh, for recording 1H- and 13C-NMR spectra and CDRI, Lucknow for mass spectra and the Department of Biotechnology, Himachal Pradesh University, Shimla for providing laboratory facilities for studying antibacterial activities.