Synthesis, characterization, and biological activity of five new mixed-ligand palladium(II) complexes with ethylenediamine and 4-toluenesulfonyl-L-amino acid dianion

Abstract

Five new palladium(II) complexes with 4-toluenesulfonyl-L-amino acid dianion and en, [Pd(en)(TsserNO)] (1), [Pd(en)(TsglyNO)] (2), [Pd(en)(TsalaNO)] · 1.5H₂O (3), [Pd(en)(TsleuNO)] · H₂O (4), and [Pd(en)(TspheNO)] · 2H₂O (5), have been synthesized and characterized by elemental analysis, IR, UV, ¹H NMR, and mass spectrometry. Crystal structure of 1 has been determined by X-ray diffraction analysis. The cytotoxicity was tested by MTT and SRB assays. The results indicate 1–5 exert cytotoxic effects against HL-60, Bel-7402, BGC-823, and KB cell lines and 5 displays the best cytotoxicity. The structure–activity relationships suggest that both amino acid and N-containing ligands have important effects on cytotoxicity.

Keywords:

• Palladium(II) complexes
• 4-Toluenesulfonyl-L-amino acid
• Ethylenediamine
• Cytotoxicity

Acknowledgments

This work was supported by the Special Foundation for State Major New Drug Research Program of China (Grant No. 2009ZX09103-139), the National Basic Research 973 Program (Grant No. 2010CB534913), Hebei Province Nature Science Fund for Distinguished Young Scholars (Grant No. B2011201164), the Nature Science Fund of Hebei Province (Grant No. B2011201135), the Key Basic Research Special Foundation of Science Technology Ministry of Hebei Province (Grant No. 11966412D), and the Key Research Project Foundation of Department of Education of Hebei Province (Grant No. ZD2010142).