Abstract
A new mononuclear copper(II) complex identified as [Cu(bpy)2(pic)](pic), where bpy represents 2,2ʹ-bipyridine and pic stands for picrate (pic), has been synthesized and characterized by elemental analysis, molar conductivity, IR and electronic spectral studies, and single-crystal X-ray diffraction. The crystal structure analysis reveals that copper(II) has a distorted square-pyramidal coordination geometry. The hydrogen bonding and π–π stacking interactions contribute to a 3-D supramolecular structure in the crystal. The DNA-binding properties of the copper(II) complex are investigated both theoretically and experimentally, revealing that the copper(II) complex interacts with herring sperm DNA (HS-DNA) by intercalation, and the molecular docking of the copper(II) complex with the self-complementary DNA duplex of sequence d(ACCGACGTCGGT)2 facilitates the binding events. The in vitro anticancer activities suggest that the copper(II) complex is active against selected tumor cell lines. The influence of the complexation of pic in the mononuclear copper(II) complexes on DNA-binding properties and in vitro anticancer activities is discussed.
A new monocopper(II) complex was synthesized and structurally characterized. The DNA-binding properties and in vitro anticancer activities of the complex were investigated.
Funding
This project was supported by the National Natural Science Foundation of China [grant numbers 51273184 and 81202399]; the Program for Science and Technology of Shandong Province [2011GHY11521]; the Natural Science Foundation of Qingdao City [grant numbers 11-2-4-1-(9)gch, 12-1-3-52-(1)-nsh 12-1-4-16-(7)-jch].