Picolinimidoamide-Cu(II) complex anchored on Fe₃O₄@SiO₂ core–shell magnetic nanoparticles: an efficient reusable catalyst for click reaction

Abstract

A Cu(II) complex supported on Fe₃O₄@SiO₂ core–shell magnetic nanoparticles (MNPs) was prepared and characterized by FT-IR, XRD, SEM, EDX, TEM, VSM, TGA, and AAS analysis. The load of Cu on picolinimidoamide ligand anchored on Fe₃O₄@SiO₂ core–shell MNPs was determined as 1.22, 1.54, and 1.70 wt% using AAS, EDX and TGA analyses, respectively. Synthesized Cu(II) complex on Fe₃O₄@SiO₂ MNPs efficiently catalyzed a click reaction between alkyl halides, alkynes, and sodium azide to synthesize corresponding triazoles in high to excellent yields. The catalyst was recovered using an external magnetic field, and recycled for subsequent reactions without substantial loss of efficiency.

Keywords:

• Click reaction
• Cu²⁺ complexes
• picolinimidoamide
• Fe₃O₄@SiO₂
• magnetic nanoparticles