Syntheses, structures, and bioactivities evaluation of three transition metal complexes with 1,2,4-triazole carboxylic derivative

Abstract

Reactions of 2-{[5-(Pyridin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetic acid (H₂L) with manganese(II), zinc(II) and cadmium(II) acetate in CH₃OH/H₂O mixture result in the corresponding metal complexes. All the obtained complexes were characterized by IR spectroscopy, elemental analyses, ESI-MS, and single-crystal X-ray diffraction. Structural analyses reveal the dinuclear complexes with the compositions [Mn₂L₂(CH₃OH)₂(H₂O)₂]·2CH₃OH (1), [Zn₂L₂(CH₃OH)₂(H₂O)₂]·2CH₃OH (2), and 1D chain structure [CdL(H₂O)]_n (3) in all complexes, H₂L is doubly deprotonated (L^2-) and serves as equilibrium anion. The carboxylate acts as monodentate ligand in 1 and 2, While μ_1,1-bridging ligand in 3. The measurement of Jack Bean urease inhibitory activity showed that 1 and 3 exhibited considerable inhibitory effects for Jack Bean urease with IC₅₀ Values of 12.4 and 2.7 μM, respectively. In addition, bioactive complexes 1 and 3 can effectively bind to bovine serum albumin (BSA), which was assessed by tryptophan emission quenching measurement

Graphical Abstract

Keywords:

• Triazole carboxylic derivative
• crystal structure
• urease inhibitory activity
• serum albumin interaction