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Abstract
2-Methylimidazolium pyridine-2,5-dicarboxylato zinc(II) dihydrate crystal (1) is synthesized and characterized by Fourier transform infrared spectroscopy (FTIR), single crystal X-ray diffraction analysis (SCXRD), thermogravimetric-differential thermal analysis (TG-DTA), scanning electron microscopy (SEM), energy dispersive X-ray analysis (EDAX), powder X-ray diffraction analysis (PXRD), proton nuclear magnetic resonance (1H NMR) studies, electronic absorption studies (UV-VIS) and DNA interaction studies. 1 was then explored for anti-microbial, anti-oxidant and anti-cancer activity. The SCXRD studies show that the compound crystallizes in the triclinic system and exhibits a distorted octahedral geometry with methyl imidazole ion as the cation. An exothermic decomposition at 400 °C implies high temperature stability in TG-DTA. PXRD confirms the phase purity of the sample. 1H NMR and UV-VIS results show that the solution structure of 1 is in agreement with SCXRD data. DNA interactions evaluated by agarose gel electrophoresis method substantiate the intercalative mode of binding. Anti-oxidant analysis shows that it exhibits good scavenging ability against DPPH and NO radicals. Anti-microbial activity suggests that 1 has better activity against Escherichia coli than Staphylococcus aureus. Further, the potential anti-cancer activities of complex indicate that the compound has good activity with a half-maximal inhibition concentration (IC50) value of 21.3 against MCF-7 human breast cancer cell line, suggesting that it may act as an anti-breast cancer drug.
Graphical Abstract
Acknowledgements
Dr. S. Jone Kirubavathy is thankful to GRG Trust (2018-2020) for the financial support. The authors are grateful to Mr. S. Satish, Department of Chemistry, VIT for his technical support in 1H NMR studies.