Synthesis, characterization and DNA-binding studies of Cu(II) and Ni(II) complexes of 1,3-diamino-2-hydroxy-propane derivatives

Abstract

Three metal complexes, [Cu(L₁)]₂ (1), [Cu(L₂)] (2) and [Ni(L₂) (H₂O)₂]·1.5H₂O (3), were synthesized using two different ligands (H₂L₁=N,N′-bis(2-hydroxy-3-methyl-benzylidene)-2-hydroxy-propane-1,3-diamine and H₂L₂=N,N′-bis(2-acetyl-indane-1,3-dione)-2-hydroxy-propane-1,3-diamine) and characterized by different spectroscopic methods. Complex 1 was studied by single-crystal X-ray diffraction analysis. In 1, each Cu(II) metal center has distorted square pyramidal structure. Complexes 2 and 3 have square planar and octahedral geometries, respectively. The interaction of calf-thymus DNA (CT-DNA) with H₂L₂ and the metal complexes (1–3) has been probed by UV–Vis absorption, photoluminescence, cyclic voltammetry and viscosity measurements.

Graphical Abstract

Keywords:

• Transition metal(II) complexes
• dimeric structure
• intercalation
• CT-DNA
• EPR study

Supplementary materials

CCDC 1911341 contains the crystallographic data information of 1. These data can be viewed and obtained free of cost at www.ccdc.cam.ac.uk/data request/cif.

Acknowledgments

The authors would like to thank SAIF IIT-MADRAS, IIT-BOMBAY, NEHU, CDRI-LUCKNOW, and Pondicherry University for crystal structure, ESR (ESI-MS and ¹H NMR) and ESI-MS. Again, we thank the UGC, New Delhi for financial assistance.