Prolidase activity in women with polycystic ovarian syndrome undergoing assisted conception

Figures & data

Figure 1. Strobe study flowchart.

Table 1. Comparison of demographic characteristics, laboratory data and in vitro fertilisation cycles outcomes.

Parameters	Control Group (n = 24)	Study Group (n = 20)	P value
Maternal age (years)*	29.11 ± 4.00	30.3 ± 4.53	0.493
Paternal age (years)*	32.21 ± 2.44	33.38 ± 2.51	0.540
BMI (kg/m^2)*	26.49 ± 5.2	25.48 ± 5.01	0.760
D3 FSH (mIU/mL)*	6.54 ± 1.48	5.95 ± 1.13	0.175
D3 LH (mIU/mL)*	5.95 ± 2.38	8.33 ± 3.55	0.923
D3 E2 (pg/mL)**	32.7 (12.9–46.7)	44.5(22–125)	0.125
Total AF count**	14 (9–15)	30(19–30)	0.041***
Number of cycle**	2 (1–2)	2(1–4)	0.115
Duration of infertility (month)**	60 (18–144)	45(18–240)	0.646
Retrieved oocyte count*	11.54 ± 5.63	14.06 ± 7.9	0.280
MII oocyte count*	9.46 ± 5.29	11.44 ± 6.47	0.318
Number of Grade 1 embryo**	1 (0–6)	0.5(0–9)	0.965
Number of Grade 2 embryo**	0 (0–2)	1(0–8)	0.071
Number of Grade 3 embryo**	0 (0–3)	0(0–3)	0.29
BQS*	96.60 ± 19.93	23.80 ± 10.16	<0.001***
Clinical pregnancy**	1 (1–2)	2(1–2)	0.126

*Values are mean ± standart deviation, ** Values are median(min-max), ***P-value of less than 0.05 was considered to be statistically significant. Abbreviations: BMI, body mass index; D3, day 3; FSH, follicle-stimulating hormone; LH, luteinizing hormone; E2, oestradiol; AF, antral follicle, MII, metaphase II; BQS, blastocyst quality scoring.

Table 2. Comparison of serum and FF prolidase level.

Predictors	Control Group (n = 24)	Study Group (n = 20)	P value
Serum prolidase level (U/L)	124.69 ± 18.74	100.17 ± 16.05	=0.005*
Follicle prolidase level (U/L)	74.39 ± 10.69	65.94 ± 8.58	<0.001

* P-value of less than 0.05 was considered to be statistically significant. Independent sample t-test.

Table 3. Correlation analysis of serum and FF prolidase levels.

Predictors		Follicle prolidase	Total AF count	BQS
Serum prolidase (U/L)	p	0.001*	0.007*	<0.001*
	r	0.491	−0.422	0.574
Follicle prolidase (U/L)	p	–	0.201	<0.001*
	r	–	−0.214	0.650

* P-value of less than 0.05 was considered to be statistically significant. Pearson’s correlation test. Abbreviations: AF, antral follicle; BQS, blastocyst quality scoring.

Data availability statement

This research data is available upon request from the corresponding author.